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C2 Mouse anti-Human, Clone: 269716, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523970

Catalog No. PIMA523970


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Description

Description

In direct ELISAs, no cross-reactivity with recombit human (rh) C1r, rhC1s, rhC3r, rhC5a, rhFactor B, or rhFactor I is observed. In Western blots, this antibody recognizes rhC2 and rhC2B. Reconstitute at 0.5 mg/mL in sterile PBS.

Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. ActivatedC1 cleaves C2 into C2a and C2b. The serine proteinase C2a thencombines with complement factor 4b to create the C3 or C5convertase. Deficiency of C2 has been reported to associated withcertain autoimmune diseases and SNPs in this gene have beenassociated with altered susceptibility to age-related maculardegeneration. This gene localizes within the class III region ofthe MHC on the short arm of chromosome 6. Alternative splicingresults in multiple transcript variants encoding distinct isoforms.Additional transcript variants have been described in publicationsbut their full-length sequence has not been determined.
Specifications

Specifications

C2
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P06681
CO2, C3/C5 convertase, complement C2, complement component C2
Mouse
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
717
Immunoprecipitation, Western Blot
269716
Unconjugated
C2
Lyophilized
C2
Mouse myeloma cell line NS0-derived recombit human Complement Component C2 Ala21-Leu752
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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