C2 Mouse anti-Human, Clone: 269716, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523970
In direct ELISAs, no cross-reactivity with recombit human (rh) C1r, rhC1s, rhC3r, rhC5a, rhFactor B, or rhFactor I is observed. In Western blots, this antibody recognizes rhC2 and rhC2B. Reconstitute at 0.5 mg/mL in sterile PBS.Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. ActivatedC1 cleaves C2 into C2a and C2b. The serine proteinase C2a thencombines with complement factor 4b to create the C3 or C5convertase. Deficiency of C2 has been reported to associated withcertain autoimmune diseases and SNPs in this gene have beenassociated with altered susceptibility to age-related maculardegeneration. This gene localizes within the class III region ofthe MHC on the short arm of chromosome 6. Alternative splicingresults in multiple transcript variants encoding distinct isoforms.Additional transcript variants have been described in publicationsbut their full-length sequence has not been determined.
|PBS with 5% trehalose and No Preservative|
|CO2, C3/C5 convertase, complement C2, complement component C2|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunoprecipitation, Western Blot|
|Mouse myeloma cell line NS0-derived recombit human Complement Component C2 Ala21-Leu752|
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