Complement C3 Goat anti-Equine, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Porcine, Rabbit, Rat, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA129715
PA1-29715 detects C3 from human, equine, hamster, Guinea pig, mouse, rabbit, rat, pig, and non-human primate samples. PA1-29715 does not cross react wtih bovine, canine, chicken, feline and sheep samples. PA1-29715 has been successfully used in immunocytochemistry, Western blot, Immunoelectrophoresis, and flow cytometry applications. The PA1-29715 immunogen is Human complement C3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The complement system provides innate defense against microbial infection and is a "complement" to antibody mediated immunity. The complement system consists of thirty five interacting plasma and membrane associated proteins which contribute to host-defense and initiate and amplify inflammation, even in the preimmune state where specific antibodies and lymphocytes are not available. In addition to the complement components themselves, this system also contains several soluble factors that prevent spontaneous complement activation from occurring in solution, as well as, several regulatory membrane associated proteins that protect host cells from accidental complement attack. Cleavage of the C3 component by either the classical pathway or the alternative pathway releases C3a and C3b. C3a appears to be important in many inflammatory responses while the C3b fragment covalently binds to the cell or bacterial surface and plays a role in opsonisation. Binding of C3b to the C4b component of the C3 convertase, results in C5 convertase (C4b3b2a) formation.
|0.05M tris HCl with 500mM NaCl and 0.1% sodium azide; pH 7.5|
|P12387, P01024, P01027, P01025, P12247, P01026|
|AHUS5, ARMD9, ASP, CPAMD1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100009121, 100060539, 100135462, 100763958, 12266, 24232, 397072, 718|
|Flow Cytometry, Immunocytochemistry, Immunoelectrophoresis, Immunofluorescence, Western Blot|
|Human complement C3|
|Equine, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Porcine, Rabbit, Rat|
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