C4BPB Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528017
PA5-28017 targets C4 binding protein B in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-28017 immunogen is recombit fragment corresponding to a region within amino acids 18 and 252 of Human C4 binding protein B. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a member of a superfamily of proteins composed predomitly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predomit isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
|Recombit fragment corresponding to a region within amino acids 18 and 252 of Human C4 binding protein B|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7|
|C4BP, C4b-binding protein beta chain|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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