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Complement C4b/C4c Rabbit anti-Human, FITC, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA128407

Catalog No. PA128407


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Description

Description

PA1-28407 detects C4c / C4b from human samples. PA1-28407 has been successfully used in immunofluorescence applications. The PA1-28407 immunogen is C4c complement isolated from complement activated human serum.

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
Specifications

Specifications

Complement C4b/C4c
Polyclonal
PBS with <0.1% sodium azide
P0C0L5
DAMC-258G8.6, C4, C4A2, C4A3, C4A4, C4A6, C4S, CO4, CPAMD2, MGC164979, RG
Rabbit
IgG
500 μL
4° C, store in dark, DO NOT FREEZE!
Primary
721
Immunocytochemistry, Immunofluorescence
FITC
C4B
Liquid
C4B
C4c complement isolated from complement activated human serum.
IgG fraction
RUO
Antibody
Polyclonal
Human
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