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Complement C4d Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA139488

Catalog No. PA139488


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Description

Description

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is tonsil tissue.

C4 plays a central role in the activation of the classical pathway of the complement system. Prior to secretion, the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha, beta and gamma). During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
Specifications

Specifications

Complement C4d
Polyclonal
PBS with 1% BSA and 0.1% sodium azide
P0C0L5
C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4F, CH, CO4, CPAMD3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, Chido form of C4, basic complement C4, complement C4-B, complement C4B1a
Rabbit
IgG
1 mL
-20° C, Avoid Freeze/Thaw Cycles
Primary
721
Immunohistochemistry (Paraffin)
Unconjugated
C4B
Liquid
C4B
Synthetic peptide derived from C-terminus of human C4d
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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