Complement C5a Rat anti-Mouse, Clone: 295108, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523910
In Western blots, this antibody does not cross-react with Recombinant mouse Complement Component C3d, Recombinant human (rh) Complement Component C3a, or rhComplement Component C5a. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
|PBS with 5% trehalose and No Preservative|
|CPAMD4, FLJ17816, FLJ17822, MGC142298|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Neutralization, Western Blot|
|E. coli-derived recombit mouse Complement Component C5a Asn679-Arg755|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok