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Carbonic Anhydrase XI Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522339

Catalog No. PIPA522339

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PA5-22339 targets CA11 in WB applications and shows reactivity with Human samples. The PA5-22339 immunogen is a recombit fragment corresponding to a region within amino acids 1 and 311 of CA11 (Uniprot IDNo.O75493). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Carbonic Anhydrase XI (CA11, CA XI) is a member of the carbonic anhydrases (CAs) family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Carbonic Anhydrase XI participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Further, Carbonic Anhydrase XI show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.


Carbonic Anhydrase XI
Recombit fragment corresponding to a region within amino acids 1 and 311 of CA11 (Uniprot IDNo.O75493)
Antigen affinity chromatography
Western Blot
0.81 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
UNQ211/PRO237, CARPX1, CA-RP II, CA-XI, CARP XI, CARP-2, carbonic anhydrase-related protein 11, carbonic anhydrase-related protein 2, carbonic anhydrase-related protein XI
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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