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Calcium Channel beta-4 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527124

Catalog No. PIPA527124


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Description

Description

PA5-27124 targets CAB4 in WB applications and shows reactivity with Human samples. The PA5-27124 immunogen is synthetic peptide corresponding to a region within amino acids 458 and 520 of Human CAB4. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

Calcium Channel beta-4
Polyclonal
Unconjugated
CACNB4
Liquid
CACNB4
Synthetic peptide corresponding to a region within amino acids 458 and 520 of Human CAB4
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 20% glycerol and 0.01% thimerosal; pH 7
O00305, Q8R0S4
CAB4, CACNLB4, EA5, EIG9, EJM, EJM4, EJM6, calcium channel voltage-dependent subunit beta 4, dihydropyridine-sensitive L-type, calcium channel beta-4 subunit, voltage-dependent L-type calcium channel subunit beta-4
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
12298, 785
Documents
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