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CADM1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524196

Catalog No. PIPA524196


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Description

Description

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Specifications

Specifications

CADM1
Polyclonal
PBS with 0.09% sodium azide
Q9BY67, Q8R5M8
BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1, TSLC-1, TSLC1/Nectin-like 2/IGSF4, immunoglobulin superfamily member 4, immunoglobulin superfamily, member 4, immunoglobulin superfamily, member 4D variant 2, nectin-like 2, nectin-like protein 2, spermatogenic immunoglobulin superfamily, synaptic cell adhesion m
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23705, 54725
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
CADM1
Liquid
CADM1
KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human CADM1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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