CABIN1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA3026
PA3-026 detects calcineurin inhibitor (cain) from human and rat tissues. PA3-026 has been successfully used in Western blot, immunoprecipitation, immunofluorescence, and ELISA procedures. By Western blot, this antibody detects an ~240 kDa protein representing cain from rat liver extract. Immunoprecipitation of cain from rat brain tissues shows an interaction between cain and amphiphysin 1, adaptin, and dynamin 1. The PA3-026 immunizing peptide is a His-tagged fusion protein corresponding to amino acid residues 1881-2173 from rat cain.Calcineurin is a widely distributed Ser/Thr, calcium and calmodulin-dependent protein phosphatase. It mediates the immunosuppressive actions of drugs such as FK506 and cyclosporin, and has also been implicated in a number of calcium-sensitive pathways in the nervous system. Calcineurin has been found to be associated with other proteins, such as calmodulin, FKBP12, the ryanodine receptor, inositol 1,4,5-trisphosphate, and a recently identified protein, calcineurin inhibitor (cain). Cain has been shown to bind calcineurin through its C-terminal tail. Recent studies have shown cain to bind to both amphiphysin 1 and calcineurin simultaneously and therefore acts as a physiological inhibitor of calcineurin. The binding of cain to amphiphysin 1 does not affect the interaction of amphiphysin 1 with other endocytic proteins. Cain, like calcineurin, is highly expressed in neurons and other tissues.
|whole serum diluted in PBS with 0.05% sodium azide|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|Peptide corresponding to amino acid residues 1881-2173 of rat cain.|
|-20° C, Avoid Freeze/Thaw Cycles|
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