Calbindin D28K Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1931
PA1-931 detects calbindin D-28k protein in rat samples. PA1-931 has successfully been used in Western blot , ELISA, immunoprecipitation and immunohistochemical procedures. By Western blot, this antibody detects a 28 kDa protein representing calbindin D from rat cerebellum and rat kidney extract. Immunohistochemical staining on paraffin sections demonstrates that calbindin D is localized to the cytoplasm in epithelial cells of distal tubules in human kidney cortex after staining with PA1-931. The PA1-931 immunizing protein corresponds to the purified 28 kDa calbindin-D protein from rat kidney.Vitamin D-dependent 28 kDa calcium-binding protein (calbindin D 28k or CB) is a member of the calmodulin superfamily of calcium binding proteins discovered in 1966 by Wasserman and Taylor. The protein has a distinct distribution in the brain and sensory system and is abundant in specific neuronal cell types. Calbindin D-28k constitutes as much as 0.1-1.5 % of the total soluble protein in brain and it may be present at intracellular concentrations up to 1 mM. Several recent studies have shown that calbindin D can protect cells from degeneration and ischemic injury under extracellular stress. In particular, this is demonstrated in the brain of Alzheimer’s disease patients. Cells containing calbindin D have a considerably lower plaque and tangles burden than those lacking this 28 kDa protein.
|PBS with 15mg/mL BSA and 0.05% sodium azide|
|P05937, P12658, P07171|
|Vitamin D-Dependent 28 kDa Calcium-Binding Protein , CB|
|-20° C, Avoid Freeze/Thaw Cycles|
|12307, 793, 83839|
|ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|28 kDa calbindin-D protein purified from rat kidney.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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