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Calcitonin Receptor Rabbit anti-Fish, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA184457

Catalog No. PA184457


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Description

Description

The use of 4% paraformaldehyde fixation, rather than formalin fixation, is recommended. A sensitive detection system is also recommended, such as a catalyzed signal amplification system. A suggested positive control for immunohistochemical applications is kidney, cultured osteoclasts. Rabbit anti Rat Calcitonin Receptor antibody recognizes the calcitonin receptor in human, mouse and rat. The calcitonin receptor is a seven transmembrane domain cell surface protein which is coupled to G protein messenger systems.

The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.
Specifications

Specifications

Calcitonin Receptor
Polyclonal
Unconjugated
CALCR
Liquid
Rabbit
IgG
100 μg
4°C or -20°C if preferred
Primary
116506, 12311, 799
ELISA, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 0.09% sodium azide
P30988, Q60755, P32214
CALCR
Synthetic peptide derived from a C-terminal sequence of rat calcitonin receptor
Protein A
RUO
Antibody
Polyclonal
Fish, Human, Mouse, Rat
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