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CaV3.3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112666

Catalog No. 01-674-820


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Description

Description

A suggested positive control for this product is rat brain lysate.

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Using co-transfection techniques we investigated the functional effects of each of the gamma subunits on the biophysics of the T-type VSCC encoded by the alpha(1I) subunit. This revealed a substantially slowed rate of deactivation in the presence of gamma(2). In contrast, there was no significant corresponding effect of either gamma(3) or gamma(4) on alpha(1l) subunit-mediated currents.(2)
Specifications

Specifications

CaV3.3
Polyclonal
Unconjugated
CACNA1I
Liquid
CACNA1I
Synthetic peptide, conjugated to KLH, corresponding to the rat alpha1I calcium channel.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.08% sodium azide
Q9P0X4
RP1-172B20.4, Cav3.3, KIAA1120
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
8911
Documents
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