anti-Calcium Channel, Voltage Gated 1C ; Polyclonal; Millipore™ (Chemicon™)

Manufacturer: EMD Millipore AB5156DEL

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Catalog No. 50-173-688


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    Antigen Calcium Channel, Voltage Gated 1C
    Conjugate Unlabeled
    Cross Reactivity Human,Mouse,Rabbit,Rat
    Format Affinity Purified
    Host Species Rabbit
    Immunogen Purified peptide (C)TTKI NMDDL QPSEN EDKS (CNC1) from 848-865 of α 1C subunit of rat brain voltage-gated Dlcium channel. Epitope loDtion is in the intracellular loop between domains II and III.
    Quantity 200μL
    Regulatory Status RUO
    Research Discipline Neuroscience
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal

    Voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform α-1c gives rise to l-type calcium currents. Long-lasting (l-type) calcium channels belong to the 'high-voltage activated' (hva) group. They are blocked by dihydropyridines (dhp), phenylalkylamines, benzothiazepines, and by w-agatoxin-IIIA (w-aga-IIIA). They are however insensitive to w-conotoxin- gvia (w-ctx-gvia) and w-agatoxin-IVA (w-aga-IVA). Calcium channels containing the α-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to dhp compounds (Swiss Prot).

    Immunohistochemistry, Immunoprecipitation, Western Blotting

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