Calpain S1/S2 Mouse anti-Human, Agarose, Clone: 28F3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112432
This antibody specifically recognizes the 28 to 30 kD small subunit of Calpain 1 and Calpain 2 (mu calpain and m calpain).The calpains are calcium-dependent cysteine proteases that are widely expressed in mammalian systems. Both m-calpain (calpain II) and m-calpain (calpain I) are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. Whereas m-calpain requires millimolar (mM) levels of calcium, m-calpain is active at micromolar (mM) concentrations of Ca++. In addition to the ubiquitously expressed m- and m- calpains, some tissue-specific calpains have been identified. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
|PBS with 50% glycerol and 3mM sodium azide; pH 7.5|
|Human Calpain protein purified from placenta.|
|-20° C, Avoid Freeze/Thaw Cycles|
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