Calpain S1/S2 Mouse anti-Bovine, Human, Clone: 28F3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112433
This antibody specifically recognizes the 28 to 30 kD small subunit of Calpain 1 and Calpain 2 (mu calpain and m calpain). It recognizes both native and denatured protein in ELISA, Western Blot and Immunoprecipitation.The calpain (calcium-dependent protease or calcium-activated neutral protease) system consists of two ubiquitous forms of calpain (mu-calpain and m-calpain), a tissue specific calpain (n-calpain), and a calpain inhibitory protein (calpastatin). The calpain system has been detected in every vertebrate tissue examined, and has been suggested to play a regulatory role in cellular protein metabolism. This regulatory role may have important implications in platelet aggregation and pathologies associated with altered calcium homeostasis and protein metabolism such as ischemic cell injury and degenerative diseases. Inhibitors of calpain have been shown to block dexamethasone and low-level irradiation induced apoptosis in thymocytes suggesting that calpain has a regulatory or mechanistic role in apoptotic cell death.
|PBS with 50% glycerol and 3mM sodium azide; pH 7.5|
|P13135, P04632, Q96L46|
|Human Calpain protein purified from placenta.|
|ELISA, Immunoprecipitation, Western Blot|
|-20° C, Avoid Freeze/Thaw Cycles|
|100300424, 281664, 826, 84290|
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