Mu-Calpain Mouse anti-Bovine, Human, Mouse, Rat, Clone: 15C10, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112434
DescriptionThe calpains are calcium-dependent cysteine proteases that are widely expressed in mammalian systems. Both m-calpain (calpain II) and μ-calpain (calpain I ) are composed of an 80 kD subunit and a 30 kD subunit. Wheras the 30 kD subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. Whereas m-clapain requires millimolar (mM) levels of calcium, μ-calpain is active at micromolar (uM) concentrations of Ca++. In addition to the ubiquitously expressed m- an μ- calpains, some tissue-specific calpains have been identified. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
|PBS with 50% glycerol and 3mM sodium azide; pH 7.5|
|Q27970, P07384, O35350, P97571|
|-20° C, Avoid Freeze/Thaw Cycles|
|12333, 281661, 29153, 823|
|ELISA, Immunoprecipitation, Western Blot|
|Human Calpain protein purified from placenta.|
|Bovine, Human, Mouse, Rat|
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