Calretinin Mouse, Unlabeled, Clone: 34, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610908
A low level of intracellular free Ca2+ is essential for a variety of cellular functions and is mediated by the sequestration of Ca2+ in the ER, by the action of plasma membrane Ca2+ pumps, and by Ca2+ binding proteins. The Ca2+ binding protein, Calretinin, is a member of the calmodulin superfamily whose members promote calcium homeostasis by acting as buffers of intracellular free Ca2+. Although Calretinin is expressed in certain populations of neurons throughout the central and peripheral nervous systems, it is primarily expressed in the olfactory bulb and auditory pathways. Calretinin most closely resembles calbindin D28k, another member of the calmodulin family. These two proteins share 58% amino acid identity and contain six EF-hand Ca2+ binding motifs. Excess Calretinin or calbindin results in decreased transcription from PCE1, a calcium responsive element in the calmodulin II promoter. This supports the role of Calretinin as a regulator of intracellular free Ca2+ levels. Furthermore, truncated forms of Calretinin have been found in certain tumor cells, but are absent from normal cells which express wild type Calretinin. Thus, these isoforms may have a role in tumorigenesis.
|Rat Calretinin aa. 38-151|
|Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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