Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Calsequestrin Mouse, Unlabeled, Clone: 51, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611652

Catalog No. BDB611652

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



Calsequestrin, a Ca2+-binding protein, is located in the lumen of the sarcoplasmic reticulum (SR) in cardiac and skeletal muscle. It binds Ca2+; with high capacity (40-50 mol Ca2+;/mol of protein) and low affinity (KD = 1mM). In the SR, calsequestrin retains large amounts of Ca2+; at locations near the ryanodine receptor/Ca2+;-release channels, which may act as a Ca2+;+-storage depot for rapid release of Ca2+; through these channels. Electron microscopy shows that calsequestrin is connected to Ca2+;-release channels via a network of anchoring filaments. These anchoring filaments contain two membrane spanning proteins called triadin and junctin, which are found in the SR. Both triadin and junctin have mixed charged clusters (KEKE motifs) that facilitate binding to both calsequestrin and ryanodine receptors. In addition, interaction between triadin and calsequestrin is enhanced at low Ca2+; concentrations. Thus, the quaternary anchoring complex that includes calsequestrin, ryanodine receptor, junctin, and triadin facilitates flow of Ca2+; ions from calsequestrin to the ryanodine receptor and concentrates Ca2+; ions at the inner face of the junctional SR membrane.

Host Species: Mouse
Clone: 51
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Mouse Calsequestrin aa. 282-389

Immunofluorescence, Western Blotting



Cell Biology
Western Blot
Affinity Purified
Murine, Rat
Product Certifications


Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit