Calumenin Mouse anti-Human, Mouse, Clone: 6B4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA518318
This antibody detects endogenous protein at a molecular weight of 45 kDa, although the predicted MW is 37 kDa. Purity is >95% by SDS-PAGE.Caluminin is a 315 amino acid Ca2+-binding member of the CREC, EF-hand protein family. Calumenin is a secreted protein t hat contains six Ca2+-binding (EF-hand) motifs and is expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. In the presence of Ca2+, Calumenin interacts with serum amyloid P component (SAP) and, together, they may play a role in the immunological defense system and participate in amyloidosis, the pathological formation of amyloid deposits in different types of tissues. Calumenin has an inhibitory effect on the vitamin K-dependent g-carboxylation system which converts vitamin K-dependent proteins to Gla-containing proteins. Calumenin may also be involved in the pathophysiology of thrombosis and/or wound healing by acting in an autocrine or paracrine manner.
|Synthetic peptide corresponding to amino acids C-terminus of human Calumenin|
|Antigen affinity chromatography|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.4|
|Crocalbin, IEF SSP 9302, CALU|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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