CaM Kinase VI (CPG16; Candidate Plasticity-related Gene 16) Mouse, Unlabeled, Clone: 5, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611736
Central nervous system plasticity is essential to the processes of learning and memory. Plasticity involves changes in synaptic transmission efficiency and results from the activation of excitatory glutamate receptors. Analysis of changes in gene expression during kainate-induced hippocampal plasticity led to the identification of a Candidate Plasticity-related Gene (CPG16). CPG16 protein is a Ser/Thr protein kinase that is also closely related to the Ca2+/calmodulin- dependent protein kinases (CaM kinases). CPG16 is 98% identical to the C-terminal region of the product of the KIAA0369 gene, a 96kDa protein whose N-terminal region strongly resembles the neural protein, doublecortin. In resting cells, Cam Kinase VI (CPG16) is found in the cytoplasm and has relatively low level of phosphorylation activity. However, treatment of cells with cAMP-elevating agents (forskolin, 8-bromo-cAMP) significantly enhances this phosphorylation activity and induces a partial shift of Cam Kinase VI (CPG16) into the nucleus. In addition, overexpression of Cam Kinase VI (CPG16) inhibits cAMP-stimulated CREB activity. Thus, Cam Kinase VI (CPG16) is Ser/Thr protein kinase that is thought to be a downstream negative regulator of cAMP/PKA-induced transcription.
Host Species: Mouse
Species Reactivity [for Features Main]: Rat
Immunogen: Rat CPG16 aa. 330-424
Immunofluorescence, Western Blotting
|CaM Kinase VI (CPG16; Candidate Plasticity-related Gene 16)|
|Immunofluorescence, Western Blot|
|Rat CPG16 aa. 330-424|
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