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Cannabinoid Receptor 1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1743

Catalog No. PA1743

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PA1-743 detects cannabinoid receptor 1 (CB1) from human and rat tissues as well as transfected rat CB1. PA1-743 has been successfully used in Western blot and immunocytochemistry procedures. By Western blot, this antibody detects an ~52 kDa protein representing CB1 from rat brain homogenate. Immunocytochemical staining of CB1 in AtT20 cells transfected with the rat CB1 gene with PA1-743 yields a pattern consistent with plasma membrane staining. PA1-743 antigen is a fusion protein containing the first 99 amino acid residues of human CB1.

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.


Cannabinoid Receptor 1
A fusion protein containing the first 99 amino acid residues from human CB1.
Affinity chromatography
Human, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
P21554, P20272
CB1, Cnr1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
1268, 25248
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