Cannabinoid Receptor 1 Rabbit anti-Amphibian, Chicken, Fish, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1745
PA1-745 detects cannabinoid receptor 1 (CB1) from human, rat, monkey, mouse, chicken, salamander and goldfish tissues. This antibody detects a few non-specific bands in NIH-3T3 and HT-29 cell lysates. PA1-745 has been successfully used in Western blot, FACS, immunohistochemistry, and immunocytochemistry procedures. By Western blot, this antibody detects a ~60 kDa protein representing CB1 and less intense bands of ~23 kDa, ~72 kDa, and ~180 kDa from rat brain homogenate. Immunocytochemical staining of CB1 in living or fixed cultured hippocampal neurons with PA1-745 results in intense, punctate staining along processes, with little staining over cell bodies. PA1-745 antigen is a fusion protein containing the first 77 amino acid residues of the rat CB1 receptor.Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
|Cannabinoid Receptor 1|
|A fusion protein containing the first 77 amino acid residues from rat CB1.|
|Amphibian, Chicken, Fish, Human, Mouse, Non-human primate, Rat|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide|
|P21554, P47746, P20272|
|-20° C, Avoid Freeze/Thaw Cycles|
|1268, 12801, 25248, 428633|
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