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Cannabinoid Receptor 1 Rabbit anti-Amphibian, Chicken, Fish, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1745

Catalog No. PA1745

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Description

Description

PA1-745 detects cannabinoid receptor 1 (CB1) from human, rat, monkey, mouse, chicken, salamander and goldfish tissues. This antibody detects a few non-specific bands in NIH-3T3 and HT-29 cell lysates. PA1-745 has been successfully used in Western blot, FACS, immunohistochemistry, and immunocytochemistry procedures. By Western blot, this antibody detects a ~60 kDa protein representing CB1 and less intense bands of ~23 kDa, ~72 kDa, and ~180 kDa from rat brain homogenate. Immunocytochemical staining of CB1 in living or fixed cultured hippocampal neurons with PA1-745 results in intense, punctate staining along processes, with little staining over cell bodies. PA1-745 antigen is a fusion protein containing the first 77 amino acid residues of the rat CB1 receptor.

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
Specifications

Specifications

Cannabinoid Receptor 1
Polyclonal
Unconjugated
CNR1
Liquid
CNR1
A fusion protein containing the first 77 amino acid residues from rat CB1.
Affinity chromatography
RUO
Antibody
Polyclonal
Amphibian, Chicken, Fish, Human, Mouse, Non-human primate, Rat
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1.0 mg/mL
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
P21554, P47746, P20272
CB1, Cnr1
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1268, 12801, 25248, 428633
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