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CNR2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1744

Catalog No. PA1-744


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Description

Description

PA1-744 detects cannabinoid receptor 2 (CB2) from human tissues. PA1-744 has been successfully used in Western blot, FACS, immunocytochemistry and immunofluorescence procedures. By Western blot, this antibody detects an ~60 kDa band from human spinal cord homogenate, and a ~40 kda band from RBL2H3 cells, representing the different glycosylated forms of CB2. PA1-744 antigen is a fusion protein containing the first 33 amino acid residues from human CB2.

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
Specifications

Specifications

CNR2
Polyclonal
Unconjugated
CNR2
Liquid
CNR2
A fusion protein containing the first 33 amino acid residues from human CB2.
Affinity chromatography
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
P34972
CB2, Cnr2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1269
Documents
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