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CEA Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA137416

Catalog No. 01-673-269

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

A suggested positive control is colon carcinoma.
Specifications

Specifications

CEA
Polyclonal
PBS with 1% BSA and <0.1% sodium azide; pH 7.6
P06731
CD66e, CEA, meconium antigen 100
Rabbit
IgG
1 mL
4° C, do not freeze
Primary
1048
Immunohistochemistry (Paraffin)
Unconjugated
CEACAM5
Liquid
CEACAM5
Purified human CEA.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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