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NLRC4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527686

Catalog No. PIPA527686


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Description

Description

PA5-27686 targets CARD12 in WB applications and shows reactivity with Human samples. The PA5-27686 immunogen is recombit fragment corresponding to a region within amino acids 1 and 168 of Human CARD12. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
Specifications

Specifications

NLRC4
Polyclonal
Unconjugated
NLRC4
Liquid
NLRC4
Recombit fragment corresponding to a region within amino acids 1 and 168 of Human CARD12
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 20% glycerol and 0.01% thimerosal; pH 7
Q9NPP4
CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF, CARD, LRR, and NACHT-containing protein, ICE-protease activating factor, NLR family CARD domain-containing protein 4, NOD-like receptor C4, caspase recruitment domain family, member 12, caspase recruitment domain-containing protein 12, ice protease-activating f
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
58484
Documents
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