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CARD8 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527695

Catalog No. PIPA527695


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Description

Description

PA5-27695 targets CARD8 in IF and WB applications and shows reactivity with Human samples. The PA5-27695 immunogen is recombit fragment corresponding to a region within amino acids 215 and 400 of Human CARD8. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.
Specifications

Specifications

CARD8
Polyclonal
Unconjugated
CARD8
Liquid
CARD8
Recombit fragment corresponding to a region within amino acids 215 and 400 of Human CARD8
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 40% glycerol and 0.01% thimerosal; pH 7
Q9Y2G2
CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN, CARD inhibitor of NF-kappaB-activating ligands, apoptotic protein NDPP1, caspase recruitment domain-containing protein 8, tumor up-regulated CARD-containing antagonist of CASP9, tumor up-regulated CARD-containing antagonist of caspase nine
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
22900
Documents
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