Cardiac Troponin I Mouse, Alexa Fluor 647, Clone: C5, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564409
The C5 monoclonal antibody specifically binds to Cardiac Troponin I (cTnI). cTnI is a ~30-kDa protein that is also known as TNNI3 and TNNC1. Troponin I is the inhibitory subunit of Troponin, which also contains the subunits Troponin C and Troponin T. Troponin aids the Ca[2+]-dependent interaction of actin and myosin, which are the main contracile components in muscle cells. cTnI is specifically expressed in cardiac tissue, while skeletal troponin I is expressed in skeletal muscle in slow and fast isoforms. Hereditary cardiomyopathy is associated with mutations in cTnI. During product development, the purified C5 monoclonal antibody detected cTnI by western blot analysis of cellular lysates and flow cytometric analysis of fixed and permeabilized cells.
|Cardiac Troponin I|
|cTnI, TNNI3, TNNC1|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Alexa Fluor 647|
|Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.|
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