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Caspase 5 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524427

Catalog No. PIPA524427

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Specifications

Specifications

Caspase 5
Polyclonal
PBS with 0.09% sodium azide
P51878
ICE(rel)III, ICEREL-III, ICH-3, CASP-5, ICE(rel)-III, TY protease, caspase 5, apoptosis-related cysteine protease, caspase-5, protease ICH-3, protease TY
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
838
Flow Cytometry, Immunohistochemistry, Western Blot
Unconjugated
CASP5
Liquid
CASP5
KLH conjugated synthetic peptide between 162-191 amino acids from the central region of human CASP5
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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