Caspase 1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141214
Suggested positive control: antigen standard for CASP1 (transient overexpression lysate), Hela whole cell extract.Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis (1). The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor.
|Synthetic peptide corresponding to residues Q(31) T R V L N K E E M E K V K R(45) of human Caspase-1.|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% sodium azide|
|ICE, IL1BC, P45|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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