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Caspase-10 Rat anti-Human, Unlabeled, Clone: 25C2, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 564972

Catalog No. BDB564972


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Description

Description

The 25C2 monoclonal antibody specifically binds to Caspase-10 (CASP10/CASP-10). Caspase-10 belongs to the caspase family of cysteine proteases and functions as an initiator caspase in the Fas ligand (CD95L/CD178)- and TNF-induced apoptosis pathways. Several isoforms have been described including, Caspase-10A, -10B, -10C, and -10D. Caspase-10 contains death domains which are involved in its binding to adaptor proteins. Following the binding of Fas ligand and TNF to their receptors (i.e., Fas/CD95 and TNFRI/CD120a, respectively), the Caspase-10/adaptor protein complexes are recruited to the intracellular death domains of the ligand-bound receptors where Caspase-10 gets cleaved. Cleaved Caspase-10 can then activate downstream caspase members, including Caspase-3 and Caspase-7, which in turn execute the apoptosis signaling pathway.

Specifications

Specifications

Caspase-10
25C2
Unconjugated
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2a, κ
100μg
Store undiluted at 4°C
Monoclonal
Western Blot
0.5mg/mL
CASP10; CASP-10; CASPA; Interleukin-1B-converting enzyme 2; FADD-like ICE2
Affinity Purified
Human Caspase-10 Recombinant Protein
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Human
Documents
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