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Caspase 10 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA529649

Catalog No. PIPA529649


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Description

Description

PA5-29649 targets Caspase 10 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-29649 immunogen is recombit protein fragment corresponding to a region within amino acids 225 and 525 of Human Caspase 10. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Specifications

Specifications

Caspase 10
Polyclonal
Unconjugated
CASP10
Liquid
CASP10
Recombit protein fragment corresponding to a region within amino acids 225 and 525 of Human Caspase 10
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Q92851
ALPS2, FLICE2, MCH4, CASP-10, FADD-like ICE2, FAS-associated death domain protein interleukin-1B-converting enzyme 2, ICE-like apoptotic protease 4, apoptotic protease MCH-4, caspase 10, apoptosis-related cysteine protease, caspase-10, interleukin-1B-converting enzyme 2
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
843
Documents
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