Caspase 10 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112507
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.A suggested positive control for this product is HeLa whole cell lysate.
|PBS with 0.02% sodium azide|
|ALPS2, FLICE2, MCH4|
|-20° C, Avoid Freeze/Thaw Cycles|
|Synthetic peptide corresponding to residues 505-521 of human FLICE2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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