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Caspase 12 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112508

Catalog No. 01-674-168


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Description

Description

A suggested positive control for this product is murine spleen tissue lysate.

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
Specifications

Specifications

Caspase 12
Polyclonal
PBS with 0.02% sodium azide
Q6UXS9, O08736, Q920D5
CASP12
Synthetic peptide corresponding to residues 100-116 of the murine caspase-12.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
Unconjugated
CASP12
Liquid
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
100506742, 12364, 156117
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