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Caspase 13 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA130684

Catalog No. PIPA130684


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Description

Description

PA1-30684 detects Caspase 13 from rat, mouse, and human samples. PA1-30684 has been successfully used in Western blot applications. A suggested positive control for this product is HL60 whole cell lysate. The PA1-30684 immunogen is synthetic peptide - amino acids 91-105 of Human Caspase 13. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.
Specifications

Specifications

Caspase 13
Polyclonal
Unconjugated
Liquid
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
Human, Mouse, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.02% sodium azide; pH 7.4
CASP13; MGC137679
Synthetic peptide corresponding to amino acids 91-105 of Human Caspase 13
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Documents
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