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Caspase 2 Mouse anti-Human, Clone: 18E809.3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141315

Catalog No. 01-676-613


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Description

Description

Suggested positive control: HL-60.

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-2 has a positive and a negative role in the regulation of the apoptotic process. Overexpression of the full Caspase-2 (Nedd2/Ich1 ) mRNA in some cell types results in apoptosis, whereas overexpression of an alternative Caspase-2 splice variant suppresses apoptosis induced by serum withdrawal. Caspase-2 may be activated in vitro by Caspase-1, Caspase-3 and the neutral serine protease granzyme B which is stored in the specialized lytic granules of cytotoxic lymphocytes.
Specifications

Specifications

Caspase 2
Monoclonal
Unconjugated
CASP2
Liquid
CASP2
Human Caspase-2.
200 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
835
Western Blot
18E809.3
ascites diluted in PBS with 0.2% gelatin and 0.05% sodium azide
P42575
CASP-2, ICH-1L, ICH-1L/1S, ICH1, NEDD2
Mouse
IgM, kappa
RUO
Antibody
Monoclonal
Human
Documents
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