Caspase 2 Precursor Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112795

Catalog No. 01-675-791

Description

By Western blot, this antibody detects bands at ∽40 and ∽50 kDa, representing the short and long forms of Caspase 2, respectively.

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.

Specifications

• Antigen: Caspase 2 Precursor
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP2
• Format: Liquid
• Gene Symbols: CASP2
• Immunogen: Synthetic peptide corresponding to 16 residues from the N-terminus of human Caspase-2.
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Mouse

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P42575, P29594
• Gene Alias: CASP-2, ICH-1L, ICH-1L/1S, ICH1, NEDD2
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μg
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 12366, 835