Caspase 2 Precursor Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112795
By Western blot, this antibody detects bands at ∽40 and ∽50 kDa, representing the short and long forms of Caspase 2, respectively.Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
|Caspase 2 Precursor|
|Synthetic peptide corresponding to 16 residues from the N-terminus of human Caspase-2.|
|Antigen affinity chromatography|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|CASP-2, ICH-1L, ICH-1L/1S, ICH1, NEDD2|
|-20° C, Avoid Freeze/Thaw Cycles|
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