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Caspase 3 Rabbit anti-Human, Invitrogen™

Rabbit Recombinant Polyclonal Antibody

Manufacturer:  Invitrogen 710431

Catalog No. PI710431


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Description

Description

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. Recombit rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombit monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombit antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombit rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predomit caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer ft.s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Specifications

Specifications

Caspase 3
Recombinant Polyclonal
0.5 mg/mL
PBS with 0.09% sodium azide
P42574
CASP-3, CPP-32,PARP cleavage protease, SREBP cleavage activity 1, Yama, apopain, caspase 3, apoptosis-related cysteine protease, caspase-3, cysteine protease CPP32, procaspase3, protein Yama
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
836
Immunocytochemistry, Immunofluorescence, Western Blot
22HCLC
Unconjugated
CASP3
Liquid
CASP3
Peptide corresponding to amino acids 30–43 of human Casp3
Protein A
RUO
Antibody
Oligoclonal
Human
Documents
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