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Caspase 3 Polyclonal Antibody, Invitrogen™

Caspase 3 Antibody, PA5-16335, from Invitrogen™. Species Reactivity: Bv, Ca, Hm, Hu, Ms, Nhp, Ov, Po, Rb, Rt; Applications: ICC, IF, IHC (P), IP, WB.

Manufacturer:  Invitrogen PA516335

Catalog No. PIPA516335

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Caspase 3 Antibody, PA5-16335, from Invitrogen. Species Reactivity: Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Ovine, Porcine, Rabbit, Rat; Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot.

Caspase 3 is ubiquitously expressed and like other caspases is synthesized as an inactive (32kDa) proenzyme. Upon activation, Caspase 3 is cleaved at Asp28-Ser29 and Asp175-Ser176 thereby generating two subunits of 17kDa and 12kDa, respectively. Recent studies have implicated that Caspase 3 is associated with the induction of apoptosis. Activation of Caspase 3 occurs in response to variety of apoptotic inducers including Fas mediated apoptosis.
Host Species: Rabbit
Cross Reactivity: Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Ovine, Porcine, Rabbit, Rat
Isotype: IgG
Immunogen: Recombinant full length human caspase 3 protein
Formulation: 500µL purified antibody (1mg/mL) in PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Synonyms: CASP-3, CPP-32,PARP cleavage protease, SREBP cleavage activity 1, Yama, apopain, caspase 3, apoptosis-related cysteine protease, caspase-3, cysteine protease CPP32, procaspase3, protein Yama
Uniprot Accession: P42574, P55213, P70677, Q08DY9, Q8MJC3, Q8MKI5, Q95ND5
Entrez GeneID: 100008840, 100689061, 12367, 25402, 397244, 403567, 408016, 443031, 836
Gene Symbol: CASP3
PA5-16335 targets Caspase 3 in immunohistochemistry (paraffin), immunoprecipitation, and western blot applications and shows reactivity with Bovine, Canine, Hamster, Human, mouse, Non-human primate, Ovine, Porcine, Rabbit, and Rat samples. The PA5-16335 immunogen is recombinant full length human caspase 3 protein.
References:
Test: IHC (P), Dilution: 1:100, Species: Hu, Reference: A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts. (Feb 2015) Oncotarget, Vol: 6, 6, 4126-43, De Luca A,Rotili D,Carpanese D,Lenoci A,Calderan L,Scimeca M,Mai A,Bonanno E,Rosato A,Geroni C,Quintieri L,Caccuri AM; Pubmed ID: 25595904
Specifications

Specifications

Caspase 3
Polyclonal
500μL purified antibody (1mg/mL) in PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Purified
CASP3
Recombinant full length human caspase 3 protein
500μL
Store at 4°C
Primary
100008840, 100689061, 12367, 25402, 397244, 403567, 408016, 443031, 836
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
P42574, P55213, P70677, Q08DY9, Q8MJC3, Q8MKI5, Q95ND5
CASP-3, CPP-32,PARP cleavage protease, SREBP cleavage activity 1, Yama, apopain, caspase 3, apoptosis-related cysteine protease, caspase-3, cysteine protease CPP32, procaspase3, protein Yama
Rabbit
IgG
RUO
Primary
Polyclonal
Bovine, Canine, Hamster, Human, Murine, Non-human Primate, Ovine, Porcine, Rabbit, Rat
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