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Caspase 4 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112797

Catalog No. 01-675-793


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Description

Description

A suggested positive control for this product is spleen or lung lysate.

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
Specifications

Specifications

Caspase 4
Polyclonal
Unconjugated
CASP4
Liquid
CASP4
Synthetic peptide corresponding to 16 residues from the N-terminus of human Caspase-4.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P49662, P70343
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
12363, 837
Documents
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