Caspase 4 Precursor Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112796
A suggested positive control for this product is spleen or lung lysate.Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
|Caspase 4 Precursor|
|PBS with 0.02% sodium azide|
|ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Western Blot|
|Synthetic peptide corresponding to 15 residues from near the center of human Caspase-4.|
|Antigen affinity chromatography|
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