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Caspase 7 Mouse anti-Human, Mouse, Rat, Clone: 25B881.1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141281

Catalog No. 01-676-611


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Description

Description

Suggested positive control: Jurkat, antigen standard for CASP7 (transient overexpression lysate), Jurkat whole cell lysate.

Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
Specifications

Specifications

Caspase 7
Monoclonal
Unconjugated
CASP7
Liquid
CASP7
Human Caspase-7.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Immunohistochemistry (Paraffin), Western Blot
25B881.1
PBS with 0.05% sodium azide
P55210, P97864
CMH-1, ICE-LAP3, MCH3
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
12369, 64026, 840
Documents
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