Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Caspase-7/MCH-3 Mouse, Unlabeled, Clone: 51, BD

Mouse Monoclonal Antibody

$206.03

Specifications

Antigen Caspase-7/MCH-3
Isotype IgG2b
Immunogen Human MCH-3 aa. 4-126
Conjugate Unconjugated
Primary or Secondary Primary
View More Specs

Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610812
View Documents
BD Biosciences
610812
50μg Each for $206.03
Add to cart
 
Description

Description

Apoptosis is induced by cysteine proteases which include Ced-3 of C.elegans, Caspase-3 (also known as CPP32, Yama, or apopain), and DCP-1 of Drosophila.. Multiple signals, such as activation of Fas and granzyme B, activate Caspase-3 which, in turn, cleaves substrates. Some substrates of Caspase-3 are PARP, MCH-3, MCH-2, U1-associated 70kDa protein, and SREBPs. Caspase-7/MCH-3 is a putative cysteine protease cloned from human Jurkat T lymphocytes. This protein shows significant homology to mammalian interleukin-1β -converting enzyme (ICE), Caspase-3, and the Caenorhabditis elegans protein Ced3. All three of these proteins are cytoplasmic cysteine proteases that induce apoptosis when overexpressed in different cell types. This apoptosis can be inhibited by coexpression of Bcl-2. Similar to ICE and Caspase-3, Caspase-7 is a proenzyme that is proteolytically cleaved into p20 and p12 subunits that form the active Caspase-7 heterodimeric complex. Similarity to ICE and Caspase-3, as well as its high levels observed in lymphocytes, suggests that Caspase-7 plays an important role in immunologic apoptosis.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

Caspase-7/MCH-3
Human MCH-3 aa. 4-126
Primary
Immunofluorescence, Western Blot
RUO
51
250μg/mL
IgG2b
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal

For Research Use Only.

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit