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Caspase 8 Mouse anti-Human, Non-human primate, Clone: 90A992, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141280

Catalog No. 01-676-610



Description

Description

MA1-41280 detects Caspase-8 in human, Rhesus monkey, and chimpanzee samples. Suggested positive control: Jurkat, antigen standard for CASP8 (transient overexpression lysate), Jurkat whole cell lysate.

Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases play a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD. Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis. In addition, Caspase 8 also reacts with Jurkat cells and Tonsil. Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family. Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
Specifications

Specifications

Caspase 8
Monoclonal
1 mg/mL
PBS with 0.05% sodium azide
Q14790
ALPS2B, CAP4, Casp-8, FLICE, FLJ17672, MACH, MCH5, MGC78473
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
841
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
90A992
Unconjugated
CASP8
Liquid
CASP8
Human Caspase-8 amino acids PVETDSEEQP
Protein G
RUO
Antibody
Monoclonal
Human, Non-human Primate
Documents
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