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Caspase 9 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA141415
Description
Suggested positive control: Hela whole cell lysate, mouse heart protein, mouse or rat heart, or HeLa, rat heart protein.
Caspase 9 (ICE-like apoptotic protease 6, ICE LAP6, apoptotic protease Mch6, apoptotic protease activating factor 3, Apaf3) is a member of the peptidase family C14 that contains a CARD domain. Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspase 9 is active as a heterotetramer, is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Further, Caspase 9 is involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase 9 promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner, and proteolytically cleaves poly(ADP- ribose) polymerase (PARP). Caspase 9 is expressed in variety of human tissues. An isoform of rat Caspase-9 has been identified in which the C terminus of full-length Caspase-9 is replaced with an alternative peptide sequence. Mutations in Caspase 9 affect brain development. In mice, insufficient Caspase 9 have resulted in abnormal cerebrum development and neuron development. In humans, dysfunctional Caspase 9 expression vary from tissue to tissue. Low levels of Caspase 9 may play a role in cancer development and neurodegenerative diseases such as Alzheimer’s Disease (AD).Specifications
Caspase 9 | |
Polyclonal | |
Unconjugated | |
P55211, Q8C3Q9 | |
CASP9 | |
Synthetic peptides corresponding to residues 345-359 and 366-383 of rat Caspase-9-CTD. | |
200 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Western Blot | |
0.5 mg/mL | |
CASP9 | |
CTD, cas9 | |
Rabbit | |
Protein G | |
RUO | |
12371, 58918, 842 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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