beta Catenin Mouse anti-Human, Mouse, Non-human primate, Rat, Clone: 6F9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA1300
MA1-300 detects beta Catenin from A431, WI-38, and MCF-7 human cell lines, mouse and rat samples. MA1-300 has been successfully used in Western blot applications. By Western blot this antibody detects a ~94 kDa protein representing beta Catenin. The MA1-300 immunogen is recombit beta Catenin protein.Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintece of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|P35222, Q02248, Q9WU82|
|Cadherin associated protein, Catenin beta 1, CATNB, CTNNB|
|Human, Mouse, Non-human primate, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|Recombit beta Catenin protein.|
|-20° C, Avoid Freeze/Thaw Cycles|
|12387, 1499, 84353|
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