beta Catenin Rabbit anti-Chicken, Human, Mouse, Rat, Xenopus laevis, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA516429
PA5-16429 targets Catenin-beta in immunohistochemistry (paraffin), immunoprecipitation, and Western blot applications and shows reactivity with mouse, rat, Xenopus, chicken, and human samples. The PA5-16429 immunogen is a synthetic peptide from the C-terminus of the beta-catenin protein.Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintece of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.
|A synthetic peptide from the C-terminus of the beta-catenin protein|
|Chicken, Human, Mouse, Rat, Xenopus laevis|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4|
|P35222, Q02248, Q9WU82, P26233|
|12387, 1499, 395964, 399274, 84353|
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