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β-Catenin Mouse, Unlabeled, Clone: 14, BD

Mouse Monoclonal Antibody

$232.00 - $458.00

Specifications

Antigen β-Catenin
Isotype IgG1
Immunogen Mouse β-Catenin aa. 571-781
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610153
View Documents Promotion Details
BD Biosciences
610153
50μg
Each for $232.00
Add to cart
 
BDB610154
View Documents Promotion Details
BD Biosciences
610154
150μg
Each for $458.00
Add to cart
 
Description

Description

β-Catenin is a 92kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. Although the α- and β-Catenins have been cloned, very little is known about their biochemical roles. However a link between β-Catenin and colon cancer has been described. β-Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

β-Catenin
Mouse β-Catenin aa. 571-781
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
14
250μg/mL
SDS
Product Certifications

For Research Use Only.

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