β-Catenin Mouse, Alexa Fluor 488, Clone: 14/Beta-Catenin, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 562505
The 14/Beta-Catenin monoclonal antibody specifically binds to Beta-Catenin ( β -Catenin). β -Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. Although the α - and β -Catenins have been cloned, very little is known about their biochemical roles. However a link between β -Catenin and colon cancer has been described. β -Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.
|CTNNB1; CTNB1; Catenin beta-1; catenin (cadherin-associated protein) beta 1|
|Mouse β-Catenin aa. 571-781|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Immunofluorescence, In vitro Assay|
|Alexa Fluor 488|
|Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok