Cathelicidin Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520513
A suggested positive control is human spleen tissue lysate. PA5-20513 can be used with blocking peptide PEP-0633. The immunogen is located within amino acids 50 - 100 of Cathelicidin.One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
|A 17 amino acid synthetic peptide near the center of the human Cathelicidin|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|HSD26, CAP-18, CAP18, CRAMP, FALL-39, FALL39, LL37; 18 kDa cationic antimicrobial protein; hCAP18|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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