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Cathelicidin Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520513

Catalog No. PIPA520513


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Description

Description

A suggested positive control is human spleen tissue lysate. PA5-20513 can be used with blocking peptide PEP-0633. The immunogen is located within amino acids 50 - 100 of Cathelicidin.

One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
Specifications

Specifications

Cathelicidin
Polyclonal
Unconjugated
CAMP
Liquid
CAMP
A 17 amino acid synthetic peptide near the center of the human Cathelicidin
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P49913
HSD26, CAP-18, CAP18, CRAMP, FALL-39, FALL39, LL37; 18 kDa cationic antimicrobial protein; hCAP18
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
820
Documents
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